Photoremovable Protecting Groups

Photoremovable protecting groups (PPGs) (also often called photocages in the literature) are used for temporary inactivation of biologically active substrates. By photoirradiation PPG could be cleaved off and biological activity restored on-demand, with a high spatiotemporal precision. The on-site liberation substrate exploited studying dynamic processes or designing targeted pharmacological interventions vitro vivo. Several chemical scaffolds have been described tested as PPGs, operating at different wavelengths. scope potential substrates is very broad, spanning from small molecules to proteins. In wider context, PPGs design various light-responsive materials well, diverse applications.